正规的买球平台

正规的买球平台:Xiaoyu Yang

Date：2018-03-01Views：1563设置

Xiaoyu Yang    Assistant Professor、PI
InstituteSchool of Physical Science and Technology
Research AreaAsymmetric Catalysis, Total Synthesis of Natural Products, Selective Protein Modification.
Contact Info.yangxy1@@shanghaitech.edu.cn


Biography
2003-2007, Nanjing University, School of Chemistry & Chemical Engineering; B.S. in Chemistry (Advisor Prof. Xiqun Jiang).
2007-2012, Shanghai Institute of Organic Chemistry, CAS; Ph.D. in Organic Chemistry (Advisor: Prof. Biao Yu).
2013.3-2015.2, University of California, Berkeley; Postdoctral Fellow (Advisor: Prof. F. Dean Toste).
2015.3-2016.6, Lawrence Berkeley National Lab，Postdoctral Fellow (Advisor: Prof. F. Dean Toste).
2016.6- ShanghaiTech University, School of Physical Sciences and Technology; Assistant Professor、PI

Research Interests
Research interest in our group include: 1) design and synthesis of novel chiral catalyst and their application in development of highly efficient and selective asymmetric reactions. 2) total synthesis of biological natural product, which features design of highly convergent and diversely synthetic route and development of novel target-orientated synthetic methods. 3) development of novel selective protein modification methods and their application in regulation of protein function.

Selected Publications


ORCID： https://orcid.org/0000-0002-0756-0671


After joining ShanghaiTech:

16. Wei Liu, Xiaoyu Yang*, Recent Advances in (Dynamic) Kinetic Resolution and Desymmetrization Catalyzed by Chiral Phosphoric Acids, Asian J. Org. Chem. 2021,  DOI: 10.1002/ajoc.202100091 (invited review, VIP paper)

  


15. Yunrong Chen, Chaofan Zhu, Zheng Guo, Wei Liu, Xiaoyu Yang* Asymmetric Synthesis of Hydroquinolines with α,α-Disubstitution via Organocatalyzed Kinetic Resolution, Angew. Chem. Int. Ed., 2021, 60, 5268 –5272.


14.  Jiawen Wang#, Sujuan Zheng#, Subramani Rajkumar, Jinglei Xie, Na Yu, Qian Peng* and Xiaoyu Yang* Chiral phosphoric acid-catalyzed stereodivergent synthesis of trisubstituted allenes and computational mechanistic studies, Nat. Commun.2020, 11, 5527.

  

13. Yongkai Pan, Qianwen Jiang, Subramani Rajkumar, Chaofan Zhu, Jinglei Xie, Shaoze Yu, Yunrong Chen, Yu-Peng He* and Xiaoyu Yang*  Kinetic Resolution of 2-N-Acylamido Tertiary Allylic Alcohols: Asymmetric Synthesis of Oxazolines, Adv. Syn. Catal. 2021, 363, 200-207 (VIP paper)

12. Wei Liu, Qianwen Jiang, Xiaoyu Yang*, Versatile Method for Kinetic Resolution of Protecting-Group-Free BINAMs and NOBINs through Chiral Phosphoric Acid Catalyzed Triazane Formation, Angew. Chem. Int. Ed., 2020, 59, 23598 – 23602

  


11. Xueqian Ye  Yongkai Pan  Yunrong Chen  Xiaoyu Yang*, Enantioselective Construction of Sulfur‐Containing Tetrasubstituted Stereocenters via Asymmetric Functionalizations of α‐Sulfanyl Cyclic Ketones, Adv. Syn. Catal. 2020, 362, 3374-3379.

10. Shunlong He, Huanchao Gu, Yu-Peng He*, and Xiaoyu Yang*，Asymmetric Aza-Diels–Alder Reactions of in Situ Generated β,β-Disubstituted α,β-Unsaturated N–H Ketimines Catalyzed by Chiral Phosphoric Acids，Org. Lett., 2020, 22, 5633–5639.


9. Donglei Wang, Qianwen Jiang and Xiaoyu Yang*，Atroposelective synthesis of configurationally stable nonbiaryl N-C atropisomers through direct asymmetric aminations of 1,3-benzenediamines, Chem Commun,  2020,  56, 6201-6204. (Selected as “Chem Commun HOT Articles' by editors)


8. Subramani Rajkumar#, Mengyao Tang# and Xiaoyu Yang*, Chiral Phosphoric Acid-Catalyzed Kinetic Resolution of 2-Amido Benzyl Alcohols: Asymmetric Synthesis of 4H-3,1-Benzoxazines, Angew. Chem. Int. Ed. 2020, 59, 2333-2337.


7. Donglei Wang#, WeiLiu#, MengyaoTang, NaYu, XiaoyuYang*, Atroposelective Synthesis of Biaryl Diamines and Amino Alcohols via Chiral Phosphoric Acid Catalysed para-Aminations of Anilines and Phenols, iScience, 2019, DOI: 10.1016/j.isci.2019.11.024

  

  

6. Xueqian Ye, Yongkai Pan and Xiaoyu Yang*, Direct enantioselective Mannich reactions of α-azido cyclic ketones: asymmetric construction of chiral azides possessing an α-quaternary stereocenter, Chem. Commun. 2019, DOI: 10.1039/c9cc08000g

 5. Subramani Rajkumar#, Shunlong He# and Xiaoyu Yang* Kinetic Resolution of Tertiary 2-Alkoxycarboxamido-allylic Alcohols by Chiral Phosphoric Acid Catalyzed Intramolecular Transesterification. Angew. Chem. Int. Ed. 2019, 58, 10315 –10319.

4. Wei Liu, Subramani Rajkumar, Weihu Wu, Ziyu Huang, and Xiaoyu Yang*, Asymmetric Synthesis of β-Indolyl Cyclopentanones and Cyclopentylamides with an All-Carbon Quaternary Stereocenter via Chiral Phosphoric Acid Catalyzed Friedel–Crafts Alkylation Reactions, Org. Lett. 2019, 21, 10, 3563-3567.

3. Subramani Rajkumar#, Jiawen Wang#, Xiaoyu Yang*, Asymmetric Transformations of α-Hydroxy Enamides Catalyzed by Chiral Br?nsted Acids,  Synlett 2019, 30(08): 869-874 (invited synpact paper)

2. Subramani Rajkumar#, Jiawen Wang#, Sujuan Zheng, Donglei Wang, Xueqian Ye, Xuejiao Li, Qian Peng,* and Xiaoyu Yang*, Regioselective and Enantioselective Synthesis of β-Indolyl Cyclopentenamides by Chiral Anion Catalysis. Angew. Chem. Int. Ed. 2018, 57, 13489 –13494

1. Shixian Lin#; Xiaoyu Yang#, S. Jia, A.M. Weeks, M. Hornsby, P.S. Lee, R.V. Nichiporuk, A.T. Iavarone, J.A. Wells, F.D. Toste, C.J. Chang, Redox-based reagents for chemoselective methionine bioconjugation. Science 2017, 355, 597-602 (# contribute equally)


Selected works before joining ShanghaiTech:

  1. Xiaoyu Yang and F. Dean Toste*. Asymmetric addition of α-branched cyclic ketones to allenamides catalyzed by a chiral phosphoric acid. Chem. Sci. 2016, 7, 2653-2656.

  2. Xiaoyu Yang, F. Dean Toste*. Direct Asymmetric Amination of α-Branched Cyclic Ketones Catalyzed by a Chiral Phosphoric Acid. J. Am. Chem. Soc. 2015, 137, 3205-3208.

  3. Xiaoyu Yang#, Tao Wu#, Robert J. Phipps, F. Dean Toste*.Advances in Catalytic Enantioselective Fluorination, Mono, Di, and Trifluoromethylation, and Trifluoromethylthiolation Reactions. Chem. Rev. 2015, 115, 826-870.

  4. Xiaoyu Yang#, Robert J. Phipps#, F. Dean Toste*. Asymmetric Fluorination of α-Branched Ketones Enabled by a Synergistic Combination of Chiral Anion Phase-Transfer Catalysis and Enamine Catalysis using Protected Amino Acids. J. Am. Chem. Soc. 2014, 136, 5225-5228.

  5. Xiaoyu Yang, Boqiao Fu, and Biao Yu*.Total Synthesis of Landomycin A, a Potent Antitumor Angucycline Antibiotic. J. Am. Chem. Soc. 2011, 133, 12433-12435.



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